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2021 World Conference on Lung Cancer (Posters)
P57. EGFR Mutational Status and PD-L1 in Early-Sta ...
P57. EGFR Mutational Status and PD-L1 in Early-Stage Brazilian Non-Small-Cell Lung Cancer
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Video Summary
The study presented focused on the frequency of EGFR mutations and PD-L1 expression in early-stage non-small cell lung cancer patients. The researchers analyzed 302 cases and found that 70% of the adenocarcinoma cases had EGFR mutations, with exome 19 and L858R being the most common mutations. The presence of EGFR mutations was associated with tobacco exposure and better overall and event-free survival. PD-L1 expression was detected in 36.7% of cases and was associated with smokers, weight loss at diagnosis, and advanced disease stage. However, PD-L1 expression did not impact overall survival, but patients with a higher PD-L1 expression had lower event-free survival.
Asset Subtitle
Leticia Ferro Leal
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Speaker
Leticia Ferro Leal
Topic
Predictive Tumor Based Assays/ Biomarkers/ Pathology
Keywords
EGFR mutations
PD-L1 expression
non-small cell lung cancer
adenocarcinoma
tobacco exposure
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