2021 World Conference on Lung Cancer (Posters)-P57. EGFR Mutational Status and PD-L1 in Early-Stage Brazilian Non-Small-Cell Lung Cancer

P57. EGFR Mutational Status and PD-L1 in Early-Stage Brazilian Non-Small-Cell Lung Cancer

Video Transcription

Video Summary

The study presented focused on the frequency of EGFR mutations and PD-L1 expression in early-stage non-small cell lung cancer patients. The researchers analyzed 302 cases and found that 70% of the adenocarcinoma cases had EGFR mutations, with exome 19 and L858R being the most common mutations. The presence of EGFR mutations was associated with tobacco exposure and better overall and event-free survival. PD-L1 expression was detected in 36.7% of cases and was associated with smokers, weight loss at diagnosis, and advanced disease stage. However, PD-L1 expression did not impact overall survival, but patients with a higher PD-L1 expression had lower event-free survival.

Asset Subtitle

Leticia Ferro Leal

Meta Tag

Speaker Leticia Ferro Leal

Topic Predictive Tumor Based Assays/ Biomarkers/ Pathology

Keywords

EGFR mutations

PD-L1 expression

non-small cell lung cancer

adenocarcinoma

tobacco exposure